Nuclear Physics Seminars

ics Nuclear
Tuesday, April 17, 2007
3:30 PM
Physics Building, Room 204
Michael Carl [Host: Donal Day]
University of Virginia
"Measurement of hyperpolarized gas diffusion at very short time scales"
Hyperpolarized 3 He diffusion MRI is a powerful tool to probe lung microstructure at a length scale inaccessible by conventional k-space MRI. For short diffusion times, ∆, time dependent diffusion measurements are sensitive to the surface to volume ratio (S/V) of the surrounding structure. Because of the high gas diffusivity (D Xe =0.14cm 2 /s, D He =0.88cm 2 /s) and the small size of alveoli (~200μm), measurement of S/V with the traditional single bipolar diffusion technique is challenging in the lung, since only small diffusion attenuation can be imparted within the short time scale regime (~200μs). Given the significance of short time scale diffusion in the assessment of lung microstructure, we developed a new technique that proves promising to enable such measurements.

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