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Condensed Matter Seminars

ics Condensed Matter
Thursday, October 30, 2003
4:00 PM
Physics Building, Room 204
Note special time.
Note special room.
Dr. Leah Shaw [Host: E. Kolomeisky]
Cornell University
"Statistical mechanics methods for genome-wide modeling of translation"
ABSTRACT:
In living cells, DNA serves as the template from which mRNA is synthesized. mRNA is then "read," or translated, by ribosomes to produce proteins. Previous studies have shown a nonlinear relationship between mRNA and protein levels, due to the complexity of the translation process. A model is under development to help explain the quantitative relationship between mRNA and protein levels for all genes in Escherichia coli. Statistical physics methods enable a detailed understanding of a single mRNA with a uniform sequence. Realistic, nonuniform sequences are a far more complex case, but mean field equations provide a good approximation for protein production rates. Details of the model will be discussed, and preliminary results comparing the model to experimental data will be presented.

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