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Condensed Matter Seminars
| Condensed Matter
Thursday, October 30, 2003
Physics Building, Room 204
Note special time.
Note special room.
Dr. Leah Shaw
[Host: E. Kolomeisky]
"Statistical mechanics methods for genome-wide modeling of translation"
In living cells, DNA serves as the template from which mRNA
is synthesized. mRNA is then "read," or translated, by ribosomes to
produce proteins. Previous studies have shown a nonlinear relationship
between mRNA and protein levels, due to the complexity of the
translation process. A model is under development to help explain the
quantitative relationship between mRNA and protein levels for all genes
in Escherichia coli. Statistical physics methods enable a detailed
understanding of a single mRNA with a uniform sequence. Realistic,
nonuniform sequences are a far more complex case, but mean field
equations provide a good approximation for protein production rates.
Details of the model will be discussed, and preliminary results
comparing the model to experimental data will be presented.
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