"Statistical mechanics methods for genome-wide modeling of translation"Dr. Leah Shaw , Cornell University [Host: E. Kolomeisky]
ABSTRACT:
In living cells, DNA serves as the template from which mRNA
is synthesized. mRNA is then "read," or translated, by ribosomes to
produce proteins. Previous studies have shown a nonlinear relationship
between mRNA and protein levels, due to the complexity of the
translation process. A model is under development to help explain the
quantitative relationship between mRNA and protein levels for all genes
in Escherichia coli. Statistical physics methods enable a detailed
understanding of a single mRNA with a uniform sequence. Realistic,
nonuniform sequences are a far more complex case, but mean field
equations provide a good approximation for protein production rates.
Details of the model will be discussed, and preliminary results
comparing the model to experimental data will be presented.
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Condensed Matter Seminar Thursday, October 30, 2003 4:00 PM Physics Building, Room 204 Note special time. Note special room. |
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